Nicotinamide Administration Improves Remyelination after Stroke

Figure 1

Increased remyelination after NAM administration was observed in vivo with MRI. (a) T2-weighted images showing the reduction of infarct size as observed at 7 d after NAM injection. (b) Representative FA color map of a brain section. The area surrounded by white line was the site of internal capsule selected for FA value determining. (c) Representative photographs of fiber tracking in the region of interest (ROI) of IC from the four groups. ROI radius: 0.45 mm. The directions of fiber tracks are color-coded with red for left–right, blue for superior–inferior, and green for anterior–posterior. (d) Quantification of the infarct size in the four groups. . (e) FA values measured in the IC at 7 d after stroke induction. for the NAM group; for the FK866 group; for the NAM+ANA-12 and saline groups. (f) FA values measured in the IC at 14 d after stroke induction. for the NAM group; for the FK866 group; for the NAM+ANA-12 and saline groups. (g) Quantitative data of fiber counts performed in the ICs of the four groups. for the NAM group; for the FK866 group; for the NAM+ANA-12 and saline groups. Data showed as mean ± SD in all histograms. , versus NAM.

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