Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer’s Disease

Table 1

Epigenetically regulated exosomal microRNAs linked to neurodegeneration.

MircoRNA	Role in neural network	Association with neurodegeneration	Biological fluids
EBV-miRNA	Intercellular communication	Gene silencing	Cerebrospinal fluid
miRNA-124a	Intercellular communication	Neuron-to-astrocyte signaling	Cerebrospinal fluid
miRNA-219	Neuronal differentiation and development	Promote CNS myelination	Cerebrospinal fluid, plasma
miRNA-133b	Neuronal plasticity	Benefit neurite remodeling	Cerebrospinal fluid
miRNA-193b	Neuronal differentiation	Affect Aβ generation	Cerebrospinal fluid, plasma
miRNA-101	Neuronal differentiation	Affect Aβ generation	Cerebrospinal fluid
miRNA-29c	Neuronal differentiation	Affect Aβ generation	Cerebrospinal fluid
miRNA-33	Neuronal maturation and apoptosis	Downregulation influence ApoE lipidation and Aβ metabolism	Cerebrospinal fluid
miRNA-195	Neuronal differentiation	Deregulate amyloid metabolism and tau phosphorylation	Cerebrospinal fluid
let-7	Neuronal inflammation	Activate the RNA-sensing TLR7	Cerebrospinal fluid
miRNA-146a	Neuronal inflammation	Modulate microglial function	Cerebrospinal fluid