Long-Term High Salt Intake Involves Reduced SK Currents and Increased Excitability of PVN Neurons with Projections to the Rostral Ventrolateral Medulla in Rats

Figure 3

HS intake increases PVN-RVLM neuronal excitability. (a, black) A representative trace of NS control neuronal firing at +200 pA current injection. (a, blue) A representative trace of HS control neuronal firing at +200 pA current injection. (a, red) A representative trace of neuronal firing at +200 pA current injection in NS with apamin. (a, purple) A representative trace of neuronal firing at +200 pA current injection in HS with apamin. (b, left) A current injection stimulus-response curve for NS controls (black) and NS with apamin (red) to graded current injections ( versus NS controls without apamin, two-way ANOVA). (b, right) A current injection stimulus-response curve for the HS group (blue) and HS with apamin (purple) to graded current injections († versus the HS group without apamin, two-way ANOVA). (c) Summary data for the slope of the linear regression line from the current injection response. The HS group showed a significant increase in the slope compared to NS controls. Treatment with apamin significantly increased the slope in both NS controls and the HS group, but less effect on the slope of the HS group compared to NS controls. ( versus NS controls; † versus the HS group, one-way ANOVA).

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