Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression

Figure 1

Statistical maps showing vAI FC differences in different brain regions between the DA, NDA, and HC groups. ANCOVA significantly increased in vAI FC among the DA, NDA, and HCs groups (, AlphaSim corrected). The FC between left vAI with left cerebellum posterior lobe, left MTG, bilateral ACC, and bilateral parietal lobe were increased; the FC between right vAI with the left putamen and right caudate were also increased; the red color bar indicates the value from ANCOVA among the three groups. DA-NDA significantly altered in vAI FC of DA patients compared with that of NDA patients (, AlphaSim corrected). DA patients showed increased left vAI FC with MTG, decreased left vAI FC with left cerebellum posterior lobe and right parietal lobe, and decreased right vAI FC with the left putamen and right caudate. DA-HC significantly changes in vAI FC of DA patients compared with that of HCs (, AlphaSim corrected). DA patients showed increased left vAI FC with left MTG and bilateral ACC, decreased left vAI FC with bilateral parietal lobe, and increased right vAI FC with the left putamen and right caudate. NDA-HC significantly altered in vAI FC of NDA patients compared with HCs (, AlphaSim corrected). The NDA patients showed increased left vAI FC with left cerebellum posterior lobe and right ACC, decreased left vAI FC with bilateral parietal lobe, and increased right vAI FC with the left putamen and right caudate. The color bar indicates the value from independent samples t-test between the three groups. ANCOVA, analysis of covariance; DA, depressed asthma; NDA, nondepressed asthma; HCs, healthy controls; FC, functional connectivity; vAI, ventral anterior insula; MTG, middle temporal gyrus.