Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression

Figure 2

ROC analyses. (a) ROC analyses differentiate DA from NDA patients by using FC values between left vAI with left cerebellum posterior lobe, left MTG, bilateral ACC, right parietal lobe, and left parietal lobe. The areas under the ROC curve for FC between left vAI with left cerebellum posterior lobe, left MTG, bilateral ACC, right parietal lobe, and left parietal lobe were 0.194 (; 95% CI: 0.058–0.331), 0.759 (; 95% CI: 0.060–0.912), 0.632 (; 95% CI: 0.450–0.796), 0.257 (; 95% CI: 0.102–0.412), and 0.294 (; 95% CI: 0.134–0.454), respectively. (b) ROC analyses differentiate DA from HC by using FC values between left vAI with left cerebellum posterior lobe, left MTG, bilateral ACC, right parietal lobe, and left parietal lobe. The areas under the ROC curve for FC between left vAI with left cerebellum posterior lobe, left MTG, bilateral ACC, right parietal lobe, and left parietal lobe were 0.700 (; 95% CI: 0.588–0.812), 0.831 (; 95% CI: 0.709–0.952), 0.828 (; 95% CI: 0.721–0.935), 0.129 (; 95% CI: 0.024–0.233), and 0.159 (; 95% CI: 0.057–0.262), respectively. (c) ROC analyses differentiate NDA from HC by using FC values between left vAI with left cerebellum posterior lobe, left MTG, bilateral ACC, right parietal lobe, and left parietal lobe. The areas under the ROC curve for FC between left vAI with left cerebellum posterior lobe, left MTG, bilateral ACC, right parietal lobe, and left parietal lobe were 0.820 (; 95% CI: 0.720–0.920), 0.599 (; 95% CI: 0.465–0.733), 0.709 (; 95% CI: 0.586–0.833), 0.301 (; 95% CI: 0.173–0.429), and 0.314 (; 95% CI: 0.189–0.438), respectively. (d) ROC analyses differentiate DA from NDA patients by using FC values between right vAI with the left putamen and right caudate. The areas under the ROC curve for FC between left vAI with the left putamen and right caudate were 0.336 (; 95% CI: 0.1700.502) and 0.306 (; 95% CI: 0.141–0.470), respectively. (e) ROC analyses differentiate DA patients from HC by using FC values between right vAI with the left putamen and right caudate. The areas under the ROC curve for FC between left vAI with the left putamen and right caudate were 0.644 (; 95% CI: 0.510–0.777) and 0.599 (; 95% CI: 0.459–0.739), respectively. (f) ROC analyses differentiate NDA patients from HC by using FC values between right vAI with the left putamen and right caudate. The areas under the ROC curve for FC between left vAI with left putamen and right caudate were 0.760 (; 95% CI: 0.651–0.868) and 0.778 (; 95% CI: 0.677–0.880), respectively. DA, depressed asthma; NDA, nondepressed asthma; HC, healthy controls; ACC, anterior cingulate cortex; FC, functional connectivity; vAI, ventral anterior insula; MTG, middle temporal gyrus.

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