Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression

Table 2

The FC between vAI with the whole brain among DA, NDA, and HCs.

Peak area	BA	Side	MNI coordinates			Voxels	Peak -value
			X	Y	Z
FC between left vAI and following brain regions
ANCOVA
Cerebellum posterior lobe	—	L	−39	−69	−39	66	12.857
Middle temporal gyrus	21	L	−51	−21	−6	77	10.0207
ACC	32	B	3	42	0	107	10.4837
Parietal lobe	7	R	15	−66	51	161	20.4306
Parietal lobe	7	L	−18	−63	54	79	13.9602
DA-NDA
Cerebellum posterior lobe	—	L	−36	−72	−42	23	−3.6785
Middle temporal gyrus	21	L	−66	−12	−6	28	4.4333
Parietal lobe	7	R	15	−66	51	52	−4.8216
DA-HCs
Middle temporal gyrus	20	L	−39	−12	−6	77	4.4481
ACC	32	B	−3	39	3	107	4.5744
Parietal lobe	7	R	15	−66	51	161	−6.2223
Parietal lobe	7	L	−18	−63	54	79	−5.2783
NDA-HCs
Cerebellum posterior lobe	—	L	−39	−69	−39	66	4.7411
ACC	32	R	6	36	6	62	3.862
Parietal lobe	7	L	−18	−63	48	20	−3.2677
Parietal lobe	7	R	30	−45	60	24	−3.6245
FC between right vAI and following brain regions
ANCOVA
Putamen	—	L	−21	9	0	54	10.0985
Caudate	—	R	15	12	15	82	13.983
DA-NDA
Putamen	—	L	−21	15	0	7	−3.2276
Caudate	—	R	15	12	18	12	−3.55
DA-HCs
Putamen	—	L	−15	18	9	7	4.0056
Caudate	—	R	21	6	9	6	2.8772
NDA-HCs
Putamen	—	L	−21	9	0	52	4.6445
Caudate	—	R	15	12	15	82	4.985

Note: ANCOVA threshold was set at (AlphaSim-corrected, cluster size >1431 mm³). The independent t-test threshold was set at (AlphaSim-corrected, cluster size >216 mm³ for left vAI and 135 mm³ for right vAI). X, Y, Z: coordinates of primary peak locations in the MNI space; MNI: Montreal Neurological Institute space; BA: Brodmann area; vAI: ventral anterior insula; L: left; R: right; B: bilateral; DA: depressed asthma; NDA: nondepressed asthma; HCs: healthy controls; ANCOVA: one-way analysis of covariance.