Abnormal Functional Connectivity of Ventral Anterior Insula in Asthmatic Patients with Depression
Table 3
ROC analyses for separating different groups.
Brain regions
AUC
value
95% CI
Sensitivity
Specificity
Cut-off point
FC between the left vAI and the following brain regions
Left cerebellum posterior lobe
DA-NDA
0.194
0.001
0.058–0.331
0.056
0.333
−0.0095a
DA-HCs
0.700
0.010
0.588–0.812
0.944
0.583
−0.1290
NDA-HCs
0.820
<0.001
0.720–0.920
0.917
0.683
−0.0808
Left middle temporal gyrus
DA-NDA
0.759
0.004
0.606–0.912
0.778
0.708
0.0932
DA-HCs
0.831
<0.001
0.709–0.952
0.778
0.833
0.0941
NDA-HCs
0.599
0.157
0.465–0.733
0.458
0.767
0.0632
Bilateral anterior cingulate cortex
DA-NDA
0.623
0.178
0.450–0.796
0.833
0.458
0.1389
DA-HCs
0.828
<0.001
0.721–0.935
0.833
0.783
0.1450
NDA-HCs
0.709
0.003
0.586–0.833
0.542
0.800
0.1554
Right parietal lobe
DA-NDA
0.257
0.008
0.102–0.412
0.278
0.292
−0.1453
DA-HCs
0.129
<0.001
0.024–0.233
0.222
0.083
−0.1336
NDA-HCs
0.301
0.005
0.173–0.429
0.500
0.150
−0.1057
Left parietal lobe
DA-NDA
0.294
0.024
0.134–0.454
0.444
0.167
−0.2058
DA-HCs
0.159
<0.001
0.057–0.262
0.333
0.117
−0.1446
NDA-HCs
0.314
0.008
0.189–0.438
0.542
0.117
−0.1489
FC between right vAI and following brain regions
Left putamen
DA-NDA
0.336
0.071
0.170–0.502
0.111
0.542
0.3462
DA-HCs
0.644
0.066
0.510–0.777
0.778
0.550
0.2277
NDA-HCs
0.760
<0.001
0.651–0.868
0.667
0.800
0.3013
Right caudate
DA-NDA
0.306
0.033
0.141–0.470
0.389
0.250
0.2506
DA-HCs
0.599
0.204
0.459–0.739
0.833
0.367
0.1431
NDA-HCs
0.778
<0.001
0.677–0.880
0.875
0.617
0.2381
Note: aThis cut-off point resulted in a sensitivity of 5.6% and a specificity of 33.3% while DA patients separating from NDA patients. The means of other cut-off points were similar. ROC: receiver operating characteristic; AUC: area under the curve; CI: confidence interval; DA: depressed asthma; NDA: nondepressed asthma; HCs: healthy controls.
