Locus Coeruleus and Dopamine-Dependent Memory Consolidation

Figure 3

Noncanonical release of DA from LC-TH⁺ axons in HPC. (a) LC electorical stimulation-induced increase of NA (top) and DA (bottom) in the medial prefrontal cortex. (a) is reproduced from [106]. (b) LC electorical stimulation-mediated D₁/D₅ receptor-sensitive facilitation of CA3–CA1 LTD in vivo. (b) is reproduced from [52]. (c) TH knockdown in LC prevents D₁/D₅ receptor-mediated enhancement of excitatory transmission in HPC. (c) is reproduced from [20]. (d) Optogenetic activation of LC-TH⁺ neurons enhances persistence of memory in a manner consistent with release of DA in HPC versus chance, t-test. (d) is reproduced from [22]. (e) Optogenetic activation of LC-TH⁺ axons in HPC produces an increase in DA release in the dorsal HPC. , t-test. (e) is reproduced from [23].

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