Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Learned Helplessness

Figure 1

Screen of effective antidepressant dose of Yueju. The doses of YJ with 1 g/kg, 1.5 g/kg, 2 g/kg, 2.5 g/kg, and 3 g/kg were used for test. (a) There was significant treatment effects on tail suspension test (TST) performed 1 hour after a single administration of YJ (ANOVA, F(5, 51) = 2.918, ) and (b) on forced swimming test (FST) carried out at 3 hours post administration (ANOVA, F(5, 49) = 15.05, ). Mice were also tested for NSF at 24 h and 72 h after administration of 2 g/kg YJ (c, d). In the separate group of animals, animals were treated with 2 g/kg and tested with TST at 1 h and 24 h (e), as well as FST at 3 h and 26 h after administration YJ (f). Immobility time was measured for the last 4 min during the 6 min testing time for TST or FST. Data are means ± SEM. , compared with control group.

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