Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on Chronic Mouse Model of Learned Helplessness

Figure 5

Intracerebroventricular microinjection of NMDA blocked Yueju (YJ) induced antidepressant effect. Mice received intracerebroventricular injection of vehicle or NMDA (1 pmol/site) 30 min prior to YJ (2 g/kg) or saline. TST was tested at 1 hour (two-way ANOVA, , ) and 24 hours (two-way ANOVA, , ) after the administration (a). FST was tested at 3 hours (two-way ANOVA, , ) and 26 hours (two-way ANOVA, , ) after the administration (b). OFT was performed 30 minutes post administration of YJ or Veh (c, d). compared with Veh-saline group; ^# compared with Veh-Yueju group.

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