Human APP Gene Expression Alters Active Zone Distribution and Spontaneous Neurotransmitter Release at the Drosophila Larval Neuromuscular Junction

<div>Distribution of mEJPs amplitudes recorded at muscle fiber 6 and 7 neuromuscular junctions from transgenic Drosophila melanogaster larvae. (a) Control, (b) APP, (c) APP+BACE, and (d) Аβ lines. Amplitude histograms show similar two-peak nature of mEJPs distributions in all lines (double Gaussian fits are shown). (e) The average amplitude of two peaks from mEJPs amplitude distribution (a–d). (f) Cumulative histogram of the mEJPs amplitude distribution. Total mEJPs number for corresponding distributions (a–d) are included. Data are presented as mean ± SEM.</div>

Neural Plasticity

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Figure 6

Figure 6: Human APP Gene Expression Alters Active Zone Distribution and Spontaneous Neurotransmitter Release at the Drosophila Larval Neuromuscular Junction

Figure 6 | Human APP Gene Expression Alters Active Zone Distribution and Spontaneous Neurotransmitter Release at the Drosophila Larval Neuromuscular Junction 