Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice

Figure 1

Experimental design. (a) Composition of the diets and percentage of total calories. Food intake (b) and body weight (c) normalized to control on day 21 of a dietary challenge (control: control diet, WD: high-cholesterol diet; versus that in the control diet, t-test). (d) Study of the effects of cholesterol-enriched diet exposure on mouse behaviour in fear conditioning test, home cage, and food competition test. (e) Study of the effects of cholesterol-enriched diet exposure on mouse performance in pellet displacement tube test, glucose tolerance, and blood biochemical parameters. (f) Study of the effects of cholesterol-enriched diet exposure on gene expression in the brain and liver.

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