Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence

Figure 3

ABR threshold in different groups at frequencies of 0.25, 0.5, 1, 2, 4, and 8 kHz. (a) shows the ABR thresholds in four groups (1: 1 × 0.5 mm near the oval (), 2: 0.5 × 0.5 mm near the oval (), 3: 1 × 0.5 mm far away from the oval (), and 4: 0.5 × 0.5 mm far away from the oval ()) at frequencies of 0.25, 0.5, 1, 2, 4, and 8 kHz. ABR threshold in all frequencies increased after the dehiscence was created in group 1 and group 2, with a statistically significant difference at the frequency of 250, 500, and 1000 Hz () in group 1 () and 1000 Hz in group 2 (). (b) and (c) show ABR threshold presurgery, postsurgery SSCD, and postdehiscence repair at frequencies of 0.25, 0.5, 1, 2, 4, and 8 kHz in groups 1 and 2. The ABR thresholds at the low frequencies 250, 500, 1000, and 2000 Hz increased notably after the dehiscence (1 × 0.5 mm near the oval and 0.5 × 0.5 mm near the oval) was created, with a statistically significant difference at the frequency of 250, 500, and 1000 Hz in group1 () and 1000 Hz in group 2 (), which was offset after the dehiscence was repaired.

(a)

(b)

(c)