Transglutaminase 2 Induces Deficits in Social Behavior in Mice

Figure 3

TG2 inhibitor, cysteamine, attenuates ER stress-induced social interaction deficits in mice. (a) Treatment paradigm. Adult male mice were injected intraperitoneally with tunicamycin (1 mg/kg in dimethyl sulfoxide, DMSO), vehicle (DMSO), or cysteamine (cys; 150 mg/kg, 30 minutes before tunicamycin injection) and tunicamycin (1 mg/kg in DMSO). Behavior was performed 12 hours after tunicamycin injection. (b–c) Cysteamine pretreatment attenuated tunicamycin-induced deficits in social behavior. (b) The three-chamber social interaction test. (E vs. M); two-way ANOVA. (c) Reciprocal social interaction test. vs. veh group; two-way ANOVA. (b–c) (vehicle); 6 (tun), 4 (cysteamine), and 6 (cysteamine + tun). Data are expressed as mean ± SEM. M: chamber housing stranger mouse; E: chamber housing an empty cage; C: center.

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