Research Article

Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats

Figure 3

Effects of antipsychotic drugs on histone deacetylase 5 (HDAC5) mRNA levels in the rat hippocampus. Rats were given a daily injection of either VEH, OLA, or HAL for 21 d in conjunction with either + stress or − stress. HDAC5 mRNA levels in the rat hippocampus were assessed using a qRT-PCR procedure. The quantitative analysis was normalized to GAPDH. versus vehicle control; versus vehicle + stress.