The Role of fMRI in the Assessment of Neuroplasticity in MS: A Systematic Review

Table 5

Longitudinal r-fMRI papers.

Authors (year)	Sample size	Age at baseline (mean)	MS duration (years)	EDSS (median)	Technique(s)	Follow-up	Functional main result(s)	Clinical correlation(s)	Structural correlation(s)
Droby et al. (2016) [72]	9 RR	42.3 (9.2)	6.2 (8.0); 1.0 (0.3)		Seed (left precuneus)	5 bimonthly follow-up periods	Higher FC in MS with periventricular lesion in the cuneus and precuneus regions; No changes in FC over time in clinically stable RR	—	—
Faivre et al. (2016) [73]	38 RR; 24 HS	36.1 (5.1); 33.1 (6.4)	10.0 (2.7); —	1.0 [0.0–6.5]; —	Graph theory	2 years	Connectivity metric increment in not disabled and decrement in disabled MS	Correlation between decrease in connectivity metrics and disability progression	No significant results

Italic font: mean; round parenthesis: standard deviation; squared parenthesis: range.