Age of Insomnia Onset Correlates with a Reversal of Default Mode Network and Supplementary Motor Cortex Connectivity

Table 1

Group differences in functional connectivity. Localization of the voxel-wise connectivity differences between PI patients and healthy controls are reported, with corresponding MNI coordinates. The results of seed-based analysis between the ICC cluster and the rest of the brain are also shown.

Procedure	Cluster MNI coordinates			k	Cluster localization	Cluster p-FDR	Increased/decreased connectivity
	x	y	z
ICC—voxel wise	14	−90	4	2328	973 voxels, primary visual cortex (left)	0.00005	↑
					1076 voxels, primary visual cortex (right)
					341 voxels, lingual gyrus (right)
					132 voxels, lingual gyrus (left)
Seed-based	38	−66	12	2893	477 voxels, brain stem	0.00003	↓
					153 voxels, frontal orbital cortex (right)
					139 voxels, hippocampus (right)
					132 voxels, temporal pole (right)
					111 voxels, lateral occipital cortex, inferior division (right)
	−42	−48	0	1702	117 voxels, middle temporal gyrus, posterior division (left)	0.0002	↓
					112 voxels, amygdala (left)
					92 voxels, hippocampus (left)
					80 voxels, parahippocampal gyrus, anterior division (left)
					51 voxels, middle temporal gyrus, temporooccipital part (left)
	0	−86	10	590	156 voxels, intracalcarine cortex (left)	0.008556	↑
					96 voxels, intracalcarine cortex (right)