Age of Insomnia Onset Correlates with a Reversal of Default Mode Network and Supplementary Motor Cortex Connectivity

Table 2

Correlation with age of onset. Results for both voxel-wise ICC and seed-based analysis are reported, with corresponding cluster size and coordinates in MNI space.

Procedure	Cluster MNI coordinates			k	Cluster localization	Cluster p-FDR	Increased/decreased connectivity
	x	y	z
ICC—voxel wise	8	38	28	5609	759 voxels, paracingulate gyrus (right)	0.00003	↑
					758 voxels, superior frontal gyrus (right)
					480 voxels, superior frontal gyrus (left)
					456 voxels, paracingulate gyrus (left)
					439 voxels, frontal pole (left)
					261 voxels, middle frontal gyrus (right)
					255 voxels, cingulate gyrus, anterior division
					243 voxels, frontal medial cortex
					125 voxels, middle frontal gyrus (left)
	8	−56	38	5103	2996 voxels, precuneus cortex	0.00004	↑
					1249 voxels, cingulate gyrus, posterior division
					122 voxels, cuneal cortex (right)
					107 voxels, intracalcarine cortex (right)
	44	−68	26	1602	1220 voxels, lateral occipital cortex, superior division (right)	0.000006	↑
					303 voxels, angular gyrus (right)
	−44	−62	24	1264	1000 voxels, lateral occipital cortex, superior division (left)	0.00007	↑
					228 voxels, angular gyrus (left)
Seed-based	2	16	56	3671	1790 voxels, supplementary motor area (left)	0.0002	↓
					1540 voxels, supplementary motor area (right)