Environmental Enrichment Induces Changes in Long-Term Memory for Social Transmission of Food Preference in Aged Mice through a Mechanism Associated with Epigenetic Processes

Figure 2

Performance of SC, EE, PL-SC, and PL-EE mice in the STFP. (a) 1-hour retention interval: there is a significant preference for the familiar food (open columns) with respect to the novel food (filled columns) for SC and EE groups, which underwent associative learning of familiar food in the breath of the demonstrator (two-way RM ANOVA post hoc analysis Holm-Sidak method, familiar food versus novel food for SC () and EE ()). (b) 24-hour retention interval (day 1). There is a significant preference for the familiar food with respect to the novel food only for EE group (two-way RM ANOVA post hoc analysis Holm-Sidak method, familiar food versus novel food for EE ()). (c) 30-day retention interval (day 30): there is a significant preference for the familiar food with respect to the novel food only for EE group (two-way RM ANOVA post hoc analysis Holm-Sidak method, familiar food versus novel food for EE ()). There is no preference for the familiar food in pseudolearning mice, PL-SC and PL-EE, for any time interval (two-way RM ANOVA post hoc analysis Holm-Sidak method () for all comparisons). ; ; error bars = SEM.

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