Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington’s Disease

Figure 5

Evaluation of cell proliferation in the dentate gyrus of 6-month-old WT and YAC128 mice treated with probucol using endogenous cell cycle markers. Cell proliferation in the SGZ of the hippocampal DG was assessed by Ki-67- (a and b) and PCNA- (c and d) immunohistochemistry. Data are presented as mean ± SEM ( mice/group), and results were analyzed with two-way ANOVA followed by the Duncan post hoc test. Representative photomicrographs of Ki-67 (b) and PCNA (d) expression in the hippocampal DG of YAC128 and WT mice treated with either vehicle or probucol (scale bar = 50 μm).

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