Intraspinal Grafting of Serotonergic Neurons Modifies Expression of Genes Important for Functional Recovery in Paraplegic Rats

Figure 2

Examples of EMG recordings from hindlimb muscles of the spinal rats (a) and (b) and spinal grafted rat (c) and (d) during exploratory behavior in the home cage (a) and (c) and during locomotor-like hindlimb movements on a treadmill induced by tail pinching (b and d). Note that in spinal control rats during spontaneous movement in the home cage, the hindlimb muscles were usually silent but a brief episode of EMG activity could be induced by a sudden touch of the rat tail (a), while in the spinal grafted rats, the spontaneous EMG activity of Sol and TA muscles could be obtained without any external intervention (c) (for more details, see [10, 13, 51, 57]. Sol: soleus muscle; TA: tibialis anterior muscle; l/r: left/right.

(a)

(b)

(c)

(d)