Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late “P300-Like” Event-Related Potential in Rats

Figure 2

(a) Schematic presentation of the auditory active oddball protocol. The experiment started with a baseline run of 250 trials (20% oddball), followed by the administration of either vehicle or donepezil. Afterwards, scopolamine or vehicle was administered and the postdrug run continued with 250 trials (20% oddball). All recordings were carried out during the dark phase of the circadian rhythm. (b) Behavioral correct response during baseline and following pharmacological treatment in animals performing an auditory discrimination cognitive task to nontarget and target stimuli. (c) Behavioral premature response during baseline and following pharmacological treatment. Data are presented as behavioral response baseline condition for each treatment group and to vehicle (), scopolamine (), donepezil (), and donepezil + scopolamine (). indicates significance difference from vehicle treatment.

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