Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear

Figure 2

ABR analysis in Myo3a mutant mice (red) and wild-type mice (black) at two months, six months, and twelve months. (a) ABR measurements for broadband click. (b) Frequency-specific pure tone stimulation of Myo3a KI/KI mice and wild-type mice at two months old (b), six months old (c), and twelve months old (d). In contrast to wild-type mice, Myo3a KI/KI mutant mice showed progressive hearing loss. Compared with WT threshold at the corresponding frequency as determined by Student’s -test. ; ; . Error bars indicate SEM. for control and mutant mice for each experiment.

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