Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear

Figure 4

The degeneration of stereocilia in the Myo3a mutant mice showed by SEM. SEM images of the hair cells in Myo3a mutant and WT mice at two months old (a, d), six months old (b, e), and 12 months old (c, f). The inner hair cell stereocilium loss was found in 6-month-old Myo3a mutant mice (e), and this phenomenon becomes more serious in 12-month-old Myo3a mutant mice (f). Scale bar = 20 μm.