Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice

Figure 6

Representation of the results derived from the present study. (a) Brief spatial exploration. (a.1) Illustration representing the newly generated cells analysed in our study that corresponds to IdU (green)- and CldU (red)- labelled cells. (a.2) Illustration representing the experimental design indicating the three groups tested with a brief spatial exploration and the control group. The illustration also indicates the duration of the explorations and the amount of time between both environment configurations. (a.3) The representative drawings indicate that newborn cells (CldU, 42 days postlabelling) mainly respond to brief spatial exploration. (b) Forced-swim stress (acute stress). (b.1) Illustration representing the newly generated cells analysed in our study that corresponds to IdU (green)- and CldU (red)- labelled cells. (b.2) The illustration represents the experimental design showing the two groups tested in experiment 2. The illustration also indicates the duration of the test and the time until the mice were sacrificed. (b.3) The representative drawings indicate that newborn cells (CldU, 42 days postlabelling) mainly respond to forced-swim exposure whereas IdU-labelled cells (21 days postlabelling) decrease activation in mice housed in standard conditions but exposed to forced swim.

(a)

(b)