Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts

Figure 5

Reduced LTP in the dentate gyrus of collybistin (Cb) KO mice as compared to WT littermates. Mean fEPSP slope (a) and population spike (b) changes are plotted as a function of time. Arrows denote the start of the theta-burst stimulation protocol consisting of 6 series of 6 trains of 6 pulses at 400 Hz with 200 ms between trains and 20 s between series. Top in (a): fEPSPs recorded before (grey) and after the induction of LTP (black). Calibration bars: 1 mV, 2 ms (adapted with permission from [74]).

(a)

(b)