Electroacupuncture Treatment Alleviates the Remifentanil-Induced Hyperalgesia by Regulating the Activities of the Ventral Posterior Lateral Nucleus of the Thalamus Neurons in Rats

Figure 6

Effects of 2 Hz-EA treatment on the RF-induced hyperalgesia in rats. (a–b) Equipment and acupoints of EA stimulation ((a) Han’s Acupoint Nerve Stimulator, LH202H; (b) a schematic diagram indicates the location of EA stimulation in rats). (c) Experimental procedure of the EA treatment. The EA stimulation was given for 30 min on the day preinfusion, continued in the 2-hour infusion, and three times (once per day) on days 1, 2, and 3 post-RF infusion. (d–e) Effects of EA treatment on the paw withdrawal threshold (PWT) in response to mechanical stimuli and the paw withdrawal latency (PWL) to thermal stimulation in rats that received RF infusion. Note that 2 Hz-EA treatment reverses the RF-induced decreases both in the PWT and PWL in rats. or versus the corresponding mock EA group, two-way ANOVA followed by the Bonferroni post hoc test, to 16 rats per group.

(a)

(b)

(c)

(d)

(e)