Review Article
Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases
Table 2
Connexin inhibitors link to the BBB permeability in vivo.
| | Disease model | Interference | Main outcome | Reference |
| Spinal cord | SCI | Cx43-asODN | Reduce vascular permeability and invasion of neutrophils in spinal cord injury | [55] | BBB | Neuroinflammation | Gap27 | Gap27 coadministered together with bradykinin reduced leakage of reporter dye from the vascular lumen into the tissue | [57] | BBB | | Global Cx30 and astrocytic-specific Cx43 deletion | Systemic astrocyte endfeet swell and increased BBB permeability with the increase in vascular and shear stress | [61] | BBB | | Global Cx30 deletion | Not affecting organization or permeability of BBB | [62] | BBB | | Astrocytic-specific Cx43 deletion | Compromises the ability of the brain to maintain immune quiescence and recruitment of immune cells without BBB breakdown | [63–66] | Embryo | | Cx43 deletion | Migration impairment of neurons through adhesive interaction with radial fibers | [69, 70] | Brain | AD | INI-1602 (microglia HC blocker) | Improve memory deficits | [114] |
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SCI: spinal cord injury; HCs: hemichannels; BBB: brain-blood barrier.
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