Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study

Table 3

Altered intrinsic functional connectivity seeded at regions with decreased GM volume in patients with JME compared with controls. CRUS 1: cerebellum crus 1; ORBsup: superior orbital frontal gyrus; MTG: middle temporal gyrus; PUT: putamen; HIPP: hippocampus; CAU: caudate; CBV: cerebellum vermis; TH: thalamus. L: left; R: right.

ROI	Brain region	MNI coordinates			T value	Voxel number
		x	y	z
R_CRUS_1	Occipital_Mid_R	27	−65	27	6.33	1027
	Occipital_Sup_L	−23	−69	36	4.84	777
	Cerebellum_8_L	−25	−69	−52	4.87	120
	Postcentral_R	58	−15	26	4.79
	Parietal_Sup_R	18	−70	47	5.46
	Postcentral_L	−33	−36	47	4.36
	Frontal_Sup_L	−19	21	54	−3.68	1054
	Temporal_Mid_L	−56	−29	−9	−4.94	271
	Frontal_Inf_Orb_L	−41	34	−18	−4.72	130
	Frontal_Inf_Orb_R	42	36	−18	−5.26	72
	Supp_Motor_Area_L	−8	21	64	−6.44
L_CRUS_1	Occipital_Mid_L	−27	−85	22	5.84	699
	Occipital_Sup_R	28	−83	22	5.44	497
	Cerebellum_6_R	28	−53	−26	5.93
	Cerebellum_6_L	−32	−44	−26	6.29
	Frontal_Mid_R	46	26	39	−4.45	744
	Frontal_Mid_L	−36	28	39	−4.14	175
	Frontal_Inf_Orb_L	−48	36	−7	−3.81	114
	Supp_Motor_Area_R	7	22	61	−4.38
CBV	Temporal_Mid_L	−48	2	−21	3.67	96
	Fusiform_L	−36	−45	−18	4.85	148
	Precuneus_R	18	−52	24	4.83	232
	Supp_Motor_Area_L	−5	18	45	−6.46	525
	Frontal_Inf_Tri_L	−36	30	0	−6.18	411
	Frontal_Inf_Tri_R	48	33	6	−4.88	336
R_TH	Cerebellum_8_R	18	−51	−60	3.92	50
	Thalamus_R	18	−15	12	3.81	25
	Thalamus_L	−15	−15	9	3.68	28
	Frontal_Sup_R	15	39	39	−5.63	174
	Frontal_Sup_Medial_L	−10	61	16	−3.93	149
R_CAU	Cerebellum_8_R	12	−60	−54	5.95	346
	Cerebellum_8_L	−14	−68	−45	4.50	171
	Caudate_L	−15	−3	21	4.39	35
	Caudate_R	15	3	21	4.23	30
	Frontal_Sup_Orb_R	12	52	−22	−5.04	168
	Postcentral_L	−40	−16	36	−4.22	100
L_CAU	Cerebellum_8_R	12	−66	−51	3.69	54
	SupraMarginal_L	−57	−33	30	4.77	107
	Paracentral_Lobule_L	−13	−26	78	−4.50	74
	Frontal_Sup_Orb_L	−13	44	−24	−3.48	68
L_PUT	Cingulum_Mid_L	−3	−15	36	4.38	55
	Hippocampus_R	36	−30	−6	4.80	32
	Frontal_Inf_Tri_L	−36	39	3	−5.78	65
	Precentral_R	36	1	51	−5.17	83
	Frontal_Inf_Tri_R	−53	19	29	−5.21	86
	Parietal_Sup_L	−24	−68	43	−3.46	122
	Parietal_Inf_L	−30	−46	45	−3.09	111
	Parietal_Sup_R	28	−64	53	−4.02	187
R_ORBsup	Insular_L	−40	0	−5	4.59	234
	Insular_R	54	5	6	5.09	284
	Cingulum_Mid_R	10	11	39	4.57	124
	Cerebellum_Crus1_R	32	−86	−30	−3.88	44
	Temporal_Inf_R	57	−10	−33	−4.57	80
	Temporal_Mid_L	−52	−9	−24	−3.78	55
	Vermis_3	0	−35	−3	−3.86	124
	Frontal_Sup_Medial_R	9	62	30	−4.34	160
L_MTG	Temporal_Sup_R	54	0	−6	4.38	190
	Temporal_Sup_L	−51	−2	−6	6.13	246
	Parietal_Inf_L	−34	−39	45	5.99	222
	Postcentral_R	36	−42	63	4.79	151
	Cerebellum_Crus1_R	13	−79	−25	−4.71	215
	Precuneus_L	−9	−54	33	−3.77	74
	Frontal_Sup_Medial_L	−9	39	45	−3.85	36
R_HIPP	Temporal_Inf_L	−47	−16	−34	4.66	61
	Frontal_Sup_Medial_R	4	61	6	4.88	127
	Frontal_Sup_Medial_L	−1	60	6	4.54
	Temporal_Inf_R	57	−33	−27	−4.16	42
	Rolandic_Oper_R	64	−4	12	−4.00	32
	Parietal_Sup_L	−21	−66	47	−4.11	145
	Occipital_Mid_R	32	−79	30	−3.69	65
	Postcentral_L	−22	−35	63	−3.82	140
	Parietal_Sup_R	16	−50	59	−3.65	47