Thrombin Inhibition Reduces the Expression of Brain Inflammation Markers upon Systemic LPS Treatment

Figure 1

LPS induces inflammation in microglia cells in vivo and in vitro. Gene expression in mouse hippocampal isolated microglia cells 24 hrs following systemic LPS injection (a). Inflammation and coagulation gene expression in N9 microglial cell line, 24 hrs following LPS treatment (b). Protein expression of coagulation and inflammation factors in N9 microglial cell line. Representative blots are presented on the left panel; each protein of interest normalized to HSC70 protein. The graph represents relative intensities that reported as fold change relative to control samples (c). Results are presented as mean ± SEM. , , , and .

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