Botulinum Neurotoxin Application to the Severed Femoral Nerve Modulates Spinal Synaptic Responses to Axotomy and Enhances Motor Recovery in Rats

<div>Drug application to the severed nerve. (a) The right femoral nerve trunk (arrow) prior to nerve injury. Proximally, the nerve is fixed by an epineural suture (short arrow) to the nearby muscle aponeurosis to prevent withdrawal of the proximal stump after nerve cut. Seen are also the 10–0 thread (upper arrowhead) used to fix the nerve and its needle (lower arrowhead), as well as the femoral vein (V). (b) The femoral nerve is transected, and the proximal stump is inserted in a self-made cup (T, see Materials and Methods) filled with drug solution. The distal nerve stump is marked by an asterisk.</div>

Neural Plasticity

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Figure 1

Figure 1: Botulinum Neurotoxin Application to the Severed Femoral Nerve Modulates Spinal Synaptic Responses to Axotomy and Enhances Motor Recovery in Rats 

Figure 1 | Botulinum Neurotoxin Application to the Severed Femoral Nerve Modulates Spinal Synaptic Responses to Axotomy and Enhances Motor Recovery in Rats 