Review Article

14-3-3 Proteins in Glutamatergic Synapses

Figure 2

14-3-3 regulates NMDA receptors and actin dynamics at postsynaptic sites. (1) 14-3-3 proteins facilitate targeting of NMDARs to the postsynaptic density, thereby regulating long-term potentiation; (2) 14-3-3 proteins might promote spinogenesis by facilitating F-actin formation.