Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice

Figure 1

Experimental procedure used in the study and changes in cerebral blood flow (CBF) in animals subjected to MCAO by a laser Doppler. (a) Trend in blood glucose and weight of mice injected intraperitoneally with STZ or vehicle (PBS) on day 22. (b) In the first experiment (A), diabetic mice were assessed with the neurologic scores and infarct size 24 hours after MCAO. In the second experiment (B), the survival of diabetic mice was observed until twenty-eight days after MCAO. (c) Laser Doppler measurements revealed that the middle cerebral artery occlusion reduced CBF sharply when the monofilament was inserted. Then cerebral blood flow showed compensatory increase and then maintained the hypoperfusion. After reperfusion, CBF could not restore to the baseline in the ischemia core for a short period of time.

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