Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

Figure 6

Sleep apnea occurrence rate in Cdkl5 +/− female mice. (a, c) Apnea occurrence rate during NREM sleep (a), REM sleep (b), and total sleep period (c). Cdkl5 +/− () and Cdkl5 −/− () mice showed an increased number of apneas during NREM sleep (a) and, consequently, an increased number of total sleep apneas (c) compared to Cdkl5 +/+ () mice. Values represent . , , and (Fisher’s LSD test after ANOVA).

(a)

(b)

(c)