Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

Figure 8

Altered ERK signaling pathway in Cdkl5 +/− female mice. (a) Western blot analysis of P-AKT-Ser 473 levels normalized to total AKT levels (left histograms) and P-ERK-Ser 42–44 levels normalized to total ERK levels (right histograms) in the hippocampus (a) and cerebellum (b) of Cdkl5 +/+ ( and , resp.), Cdkl5 +/− ( and , resp.), and Cdkl5 −/− ( and , resp.) mice. Immunoblots are examples from one animal of each experimental group. Data are expressed as a percentage of the values of Cdkl5 +/+ mice. Values are represented as . and (Fisher’s LSD after ANOVA).

(a)

(b)