Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

Table 1

Comparison of behavioral phenotypes in Cdkl5 KO female and male mice.

		Cdkl5 +/−	Cdkl5 −/−	Cdkl5 −/Y
Olfactory performance	Buried food test	+++	+++	na
Autistic-like features	Nest building 22 hours	+++	+++	+++	[22]
	Marble burying	++	+++	na
Motor function	Rotarod	+	+	++	[22, 32]
	Open field	+	++	+++	[32]
Learning and memory	Morris water maze learning	++	+++	+++	[20, 24]
	Morris water maze probe	+++	+++	+++	[20, 24]
	Passive avoidance	++	++	+++	[24]
Breathing	Sleep apneas	+++	+++	+++	[40]

Phenotypes are compared to their sex-matched wild-type condition. +, 10–25% of difference; ++, 25–50% of difference; and +++, >50% of difference. na: not assessed. Average of all trials; average of latency day 2–day 5.