Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats

<div>Functional hindlimb recovery promoted after AAV-CNTF gene therapy and cellular transplantation as assessed by open-field locomotion (BBB). Significant functional improvements were observed following AAV-CNTF<sup>mCherry</sup> (red), AAV-CNTF<sup>mCherry</sup> + nonviable rMPC (black), and AAV-CNTF<sup>mCherry</sup> + viable rMPC (blue) treatment compared to AAV-GFP-treated control animals (green) generally from day 21 after SCI onwards, although statistically significant differences were not maintained at all time points (<svg height="13.532pt" id="M34" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 79.1558 13.532" width="79.1558pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 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Standard deviation is shown.</div>

Neural Plasticity

fig4

Figure 4

Figure 4: Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats 

Figure 4 | Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats 