Research Article
Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity
| | All patients | More severe at baseline (FM ≤ 36) | Less severe at baseline (FM > 36) | |
| | n | 18 | 9 | 9 | | | Age (years) | 61 ± 10 | 60 ± 10 | 62 ± 11 | 0.79 | | Sex | 3 F/15 M | 2 F/7 M | 1 F/ 8 M | 0.62 | | Time poststroke (months) | 4.1 ± 0.97 | 4.5 ± 0.84 | 3.7 ± 0.96 | 0.07 | | Side of stroke | 10 L/8 R | 5 L/4 R | 5 L/4 R | 1.0 | | Infarct volume (cc) | 27 ± 45 (0.5–166) | 24 ± 37 (0.5–116) | 30 ± 37 (0.7–165) | 0.85 | | Corticospinal tract integrity | 0.39 ± 0.11 | 0.37 ± 0.12 | 0.41 ± 0.10 | 0.31 | | Mean baseline Fugl-Meyer (normal = 66) | 39 [20–60] | 30 [20–35] | 47.5 [38–60] | 0.0003 | | NIH stroke scale (normal = 0) | 4 ± 1 | 3.7 ± 1 | 4.3 ± 0.9 | 0.18 | | Nottingham sensory scale (normal = 17) | 13 ± 4.5 | 13 ± 5.4 | 14 ± 3.7 | 0.76 | | Mini-mental state exam (normal = 30) | 28 ± 2.6 | 28 ± 1.8 | 28 ± 3.3 | 0.65 | | Geriatric depression scale (normal = 0) | 3.2 ± 2.1 | 3.4 ± 1.4 | 2.9 ± 2.7 | 0.59 |
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Values are the mean ± SD (range) or median [IQR]. Measured as fractional anisotropy within ipsilesional cerebral peduncle. |
