Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats

<div>EA suppressed the facilitated spinal LTP in colitis rats. High-frequency and high-intensity conditioning stimulation (CS) was applied to the sciatic nerve to induce the spinal LTP at the L4-L5 segment in the control (a), vehicle (b), colitis (c), and EA (d) groups. After CS, the CFEFP was continuously recorded for at least 3 h. The amplitude of the field potentials after CS was normalized and expressed as the percentage of the baseline control value. Arrows indicate the time point of CS application. The enhanced spinal LTP in colitis rats was suppressed by EA treatment (e). Representative traces (a1, b1, c1, and d1) are the basal CFEFP recorded before CS; traces (a2, b2, c2, and d2) show the increased CFEFP obtained after CS. 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Neural Plasticity

fig6

Figure 6

Figure 6: Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats 

Figure 6 | Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats 