Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice

Figure 3

Spontaneous GABAergic network activity is not altered in CA3 pyramidal neurons of Shank3^-/- mice at P15. (a) Example of traces of sIPSCs recorded in whole-cell patch clamp at +10 mV in WT (in black) and Shank3^-/- (in red) mice at P15. (b, c) Bar graphs show the average frequency (b) and amplitude (c) of sIPSCs. (d, e) Cumulative probability distributions of iei (d) and amplitude (e) in WT and Shank3^-/- mice. Data are presented as . (b–e) for WT and for Shank3^-/- mice.

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