Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia

Figure 11

Indices for pairs of receptor subunits and modeling of predicted decay kinetics for a population of NMDARs and GABA_ARs. Scatterplots showing the average expression of the predicted population kinetics ((a) NMDAR, (b) GABA_AR) for the regions of the V1 (columns) across normal development. Histograms and scatterplots showing the average expression of the predicted population kinetics ((c) NMDAR, (d) GABA_AR) for the regions of the V1 (columns) across treatment conditions. (e) The predicted population kinetics are plotted for both GABA_ARs (-values) and NMDARs (-values) for normally reared animals age range 2 wks adult with the curve representing the trajectory of the relationship between these features (black dots and line, see (a) and (b)). Also, the data are plotted for 5 wk MD (grey dot), RO (blue dot), and BD (green dot). The relationship between NMDAR and GABA_AR kinetics during BV treatment for 1 hr (orange) to 4 d (red) is plotted, and the line uses the functions fit to the data in (c) and (d). For exact values, Pearson’s , and equations for the curve-fits, see Supplemental Table 11-1.