Alterations of the Brain Microstructure and Corresponding Functional Connectivity in Early-Blind Adolescents

Table 3

Brain regions with significant changes in diffusion tensor imaging metrics.

Between-group comparison	DTI parameter changes	Localizations of peak voxels	Abbreviations	Cluster size (voxels)	score	Peak MNI
						NLP vs. NSC (, AlphaSim corrected)	FA reduction	Left occipital lobe/subgyral	OG.L	5196	-7.73	-32	-62	-2
Right parahippocampal	ParaHIP.R	978	-10.06	12	2			-22
Right superior occipital gyrus	SOG.R	255	-8.34	24	-92			32
MD elevation	Left lingual	LING.L	3698	5.85	-28		-54	-4
	Right lingual	LING.R	3596	5.84	20		-54	2
RD elevation	Right lingual	LING.R	4030	6.74	14		-80	0
	Right parahippocampal	ParaHIP.R	7113	7.07	10		4	-18
LP vs. NSC (, AlphaSim corrected)	FA reduction	Left parahippocampal	ParaHIP.L	319	-6.58	-12	2	-20
		Left middle occipital gyrus	MOG.L	198	-5.98	-26	-100	2
		Left occipital lobe/subgyral	OG.L	224	-5.71	-32	-68	-2
		Left lingual	LING.L	142	-5.11	-4	-74	-4
		Right middle occipital gyrus	MOG.R	62	-5.99	38	-70	0
		Left cuneus	CUN.L	154	-5.98	-8	-84	30
		Right parietal lobe/subgyral	PG.R	120	-6.65	32	-40	24

Abbreviations: LP: early-blind adolescents with residual light perception; NLP: early-blind adolescents without light perception; NSC: normal-sighted controls; FA: fractional anisotropy; MD: mean diffusivity; RD: radial diffusivity; and MNI: Montreal Neurological Institute.