MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1

Figure 1

Chronic-constriction injury (CCI) induces mechanical allodynia and thermal hyperalgesia and increases MZF1 and TRPV1 levels in L4/5 DRGs. (a, b) Behavioral data showing the reduction of paw-withdrawal threshold (PWT) (a) and paw-withdrawal latency (PWL) (b) following CCI. , , and vs. baseline value (two-way ANOVA). (c) qRT-PCR data showing an increase in mRNA expression of MZF1 and TRPV1 in L4/5 DRGs following CCI. and vs. the sham group (one-way ANOVA). (d) Western blotting data showing an increase in protein expression of MZF1 and TRPV1 in L4/5 DRGs following CCI. and vs. the sham group (one-way ANOVA).

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