MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury

Figure 1

Decrease in spine density after controlled cortical impact (CCI). (a) Schematic representation of injured area. Nissl-stained brain sections from animals at 1 and 7 days after CCI (CCI: animals after controlled cortical impact; sham: animals subjected to craniectomy without cortical injury). (b) Spine density (number of spines per 1 μm of dendrite length) in ipsi- and contralateral 2nd and 3rd cortex layers of C57Bl6/J mice, 1 and 7 days after CCI and sham procedures; right panel shows representative dendrites pictures. (c) Spine density in ipsi- and contralateral dentate gyrus of C57Bl6/J mice, 1 and 7 days after CCI and sham procedures; right panel shows representative dendrite pictures. Data are presented as . Statistical analysis was carried out using one-way ANOVA followed by Tukey’s post hoc test. Asterisks indicate statistical significance from the CCI and sham groups, respectively. ; ; .

(a)

(b)

(c)