Sudden Intrabulbar Amyloid Increase Simultaneously Disrupts Olfactory Bulb Oscillations and Odor Detection

Figure 3

The activity of the OB in the presence of odors is reduced by the acute administration of Aβ_1-42. (a) Top: representative recordings of the right (upper trace) and left (lower trace) OBs in the presence of odors before (baseline) and 60 min after the administration of the inverse sequence Aβ_42-1. Bottom: the spectrogram for the recording of one of the OBs. (b) The same as in (a), but for animals given Aβ_1-42. (c) Quantification of the change in power (normalized as % of control; i.e., period before odor presence) of OB activity in the presence of odors and in broad-band frequency (1-59 Hz) before (baseline) and 60 min after the administration of either the inverse sequence Aβ_42-1 () or Aβ_1-42 (). The dotted line represents control levels. (d) Quantification of the power (normalized as % of baseline) of OB activity in the presence of odors in the following frequency bands: theta (1-12 Hz), beta (13-35 Hz), and gamma (36-59 Hz), 60 min after the administration of either the inverse sequence Aβ_42-1 () or Aβ_1-42 (). The dotted line represents baseline. (e) Representative cross-correlograms of the activities of both OBs in the presence of odors before (baseline) and 60 min after the administration of either the inverse sequence Aβ_42-1 (left cross-correlograms) or Aβ_1-42 (right cross-correlograms). (f) Quantification of the peak correlation (at zero lag) of OB activities in the presence of odors before and 60 min after the administration of either the inverse sequence Aβ_42-1 () or Aβ_1-42 (). denotes a significant difference compared to baseline ().

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