Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice

Figure 1

Experimental design, body weight changes, and anxiety testing. (a) Schematic of the chronic restraint stress (CRS) treatment schedule, behavioral testing experiment, and sampling. (b) Body weights in the four groups of mice were measured on days 1, 8, 16, and 24 after CRS commencement. represents a comparison between control and CRS mice on days 8, 16, and 24. Memantine intervention had no significant effect on body weight recovery. (c, d) Memantine decreased CRS-induced anxiety in the elevated plus maze test. Time in the open arms, time in the closed arms, and the numbers of open- and closed-arm entries were measured on days 14 (c) and 27 (d). The results are shown as means ± SEM ( in each group). ; ; . BW: body weight; EPM: elevated plus maze; Con: control; CRS: chronic restraint stress.

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