Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice

Figure 6

Memantine enhances tau phosphorylation in hippocampus and several subregions of the cerebral cortex of mice during 28-day chronic restraint stress (CRS). Western blotting detected the AT8 antibody-labeled phosphorylated tau in (a) hippocampus, (b) anterior cingulate cortex, (c) posterior cingulate cortex, (d) parietal cortex, (e) occipital cortex, and (f) entorhinal cortex, and the quantitative analysis normalized against GAPDH. The results are shown as means ± SEM ( in each group). ; ; . Con: control.

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