Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice

Figure 9

Memantine regulates N-methyl-D-aspartate receptor (NMDAR) expression in mice subjected to 28 consecutive days of chronic restraint stress (CRS). (a, c) Western blotting of the frontal cortex extracts showed that CRS increased the protein expression levels of the NMDAR subunits GluN2A and GluN2B. In contrast to the CRS group, low-dosage memantine partially suppressed GluN2A expression while tending to increase the expression of GluN2B. High-dosage memantine increased the protein expression levels of GluN2B; however, it did not have a statistically significant effect on GluN2A levels. (b, d) Densitometric quantification of the bands in (a) and (c). The results are shown as means ± SEM ( in each group); β-actin was used as a loading control. ; . Con: control.

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