Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus

Figure 1

Effects of treatment with fluoxetine, metformin, or their combination on depression-like behavior. (a) Liking-type anhedonia. Saccharin preference significantly decreased following exposure to stressful procedure. After the first week of treatment, FLX-MET mice displayed an increased saccharin preference compared to both VEH, FLX, and MET mice. (b) Wanting-type anhedonia. The breakpoint level was significantly reduced after the unpredictable chronic mild stress. Following the first week of treatment, FLX-MET mice showed a significant increase of the breakpoint level compared to both FLX and MET mice. Treatments as indicated in the legend, mice per group. pre- vs poststress, and vs VEH, and vs FLX, and and vs MET. Data are presented as .

(a)

(b)