Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke

Figure 1

Optogenetic targeting of neural circuits in the motor recovery after ischemic stroke in the mouse brain. The illustration depicts several targeting circuits or sites, (1) including stimulation of ischemic infarcted iM1 [31], (2) stimulation of efferent iM1-thalamus-spinal circuits [9], (3) stimulation of afferent thalamocortical circuits [46], (4) stimulation of multisynaptic projections of cLCN-thalamus-M1 [39], and (5) stimulation of striatum-SVZ projection for neurogenesis [54, 58]. Afferent and efferent circuits are distinguished as blue and red color, respectively.